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Good nutrition, including trace mineral nutrition, plays an important role in preventing viral infections as well as improving the immune response if viruses do infect the animal

These exerkines act through autocrine, paracrine, or endocrine mechanisms to mediate inter-organ communication, playing essential roles in regulating nervous system function, attenuating neuroinflammation, and promoting neural repair (Chow et al., 2022

In experimental models, it may be included as a reference peptide when studying stress-response pathways, circadian-adjacent biology, and downstream molecular readouts linked to brainbody communication

Rajaram and Subramanian, 2018)